Photocatalytic Synthesis of Isoquinolinediones via the Cascade Reaction of <i>N</i>-Alkyl-<i>N</i>-methylacrylamides with Diazo Compounds

Abstract

Carbon radicals generated from acceptor diazo compounds prefer to add to electron-rich olefins and heteroarenes due to their containing electron-withdrawing groups. Herein, a cascade reaction of acceptor diazo compounds with electron-deficient olefins is developed. In the presence of visible light and Ru catalyst, diazo compounds generate carbon radicals via proton-coupled electron transfer process, followed by addition with various N -alkyl- N -methylacrylamides and subsequent cyclization to give a series of acyl-substituted isoquinolinediones.

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