Grape seed extract supplementation modulates hepatic lipid metabolism in rats. Implication of PPARβ/δ
Eduardo Guisantes-Batán, Lorena Mazuecos, Blanca Rubio, Gema Pereira‐Caro, José Manuel Moreno‐Rojas, Antonio Andrés, Sergio Gómez‐Alonso, Nilda Gallardo
Abstract
, as well as the activation of AMPK triggered by GSE consumption. Our data suggest that PPARβ/δ activation is involved in the metabolic reprogramming effects of chronic GSE consumption in young rats, by modulating, at least, part of the transcriptional programs that maintain hepatic and systemic fuel homeostasis.
Topics & Concepts
Lipid metabolismPeroxisome proliferator-activated receptorMetabolismPeroxisomePharmacologyChemistryBiologyInternal medicineEndocrinologyBiochemistryMedicineReceptorCholesterol and Lipid MetabolismPeroxisome Proliferator-Activated ReceptorsLiver Disease Diagnosis and Treatment