A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia

Andrew D. Krystal, Diego A. Pizzagalli, Moria J. Smoski, Sanjay J. Mathew, John I. Nürnberger, Sarah H. Lisanby, Dan V. Iosifescu, James W. Murrough, Hongqiu Yang, Richard D. Weiner, Joseph R. Calabrese, Gerard Sanacora, Gretchen Hermes, Richard S.E. Keefe, Allen W. Song, Wayne K. Goodman, Steven T. Szabo, Alexis E. Whitton, Keming Gao, William Z. Potter