Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades
Xiuchao Geng, Yuhao Zhang, Qiang Li, Xi Wang, Wentao Yu, Liang Shi, Xiaomeng Lin, Shao-Guang Sun, Hong Wang
Abstract
A) modifications of the identified circRNAs were also predicted. Through multilevel research screening, 4 circRNAs (hsa_circ_0000915, hsa_circ_0127664, hsa_circ_0008362, and hsa_circ_0001467) were associated with glioma of different pathological grades and could be preferred candidates for subsequent functional analysis. Therefore, circRNAs are associated with the different pathological grades of glioma and reveal their potential critical regulatory function. CircRNAs might provide vital molecular biomarkers and potential therapeutic targets for glioma.
Topics & Concepts
GliomaCircular RNAComputational biologyBiologyLong non-coding RNAmicroRNAGeneticsRNAGeneCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research