Deoxyelephantopin induces apoptosis via oxidative stress and enhances gemcitabine sensitivity <i>in vitro</i> and <i>in vivo</i> through targeting the NF-κB signaling pathway in pancreatic cancer
Daolin Ji, Xiangyu Zhong, Peng Huang, Pengcheng Kang, Kaiming Leng, Wangyang Zheng, Zhidong Wang, Yi Xu, Yunfu Cui
Abstract
experiments showed that DET not only inhibited pancreatic tumor growth and metastasis but also amplified the antitumor capacity of GEM, which was related to the downregulation of NF-κB and its downstream gene products. In summary, it is possible that DET could be developed as a single agent or combined with conventional chemotherapy drugs to improve the treatment of pancreatic cancer.
Topics & Concepts
GemcitabinePancreatic cancerCancer researchApoptosisIn vivoMetastasisChemotherapyOxidative stressCancerPancreatic tumorMedicineDownregulation and upregulationSignal transductionPharmacologyBiologyInternal medicineCell biologyBiochemistryGeneBiotechnologyNatural Compounds in Disease TreatmentGinger and Zingiberaceae researchSesquiterpenes and Asteraceae Studies