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Rhabdomyolysis Secondary to COVID-19 Vaccination

Mariah Mack, Laura Nichols, Dubert M. Guerrero

2021Cureus35 citationsDOIOpen Access PDF

Abstract

Rhabdomyolysis has been described as a complication of coronavirus disease 2019 (COVID-19) infection, but few cases of rhabdomyolysis associated with COVID-19 vaccination have been reported. We described a case of an 80-year-old male who developed rhabdomyolysis two days after receiving his second dose of the Moderna COVID-19 vaccine. He presented with severe weakness, myalgias, and an initial creatinine kinase (CK) of 6,546 IU/L that improved with intravenous fluids. Common causes of rhabdomyolysis were excluded including statin use, strenuous exercise, and trauma. With the increasing immunization efforts against COVID-19, physicians should consider the possibility of rhabdomyolysis when a patient presents with neuromuscular complaints following vaccination.

Topics & Concepts

RhabdomyolysisMedicineVaccinationCoronavirus disease 2019 (COVID-19)ComplicationPediatricsInternal medicineDiseaseImmunologyInfectious disease (medical specialty)Muscle and Compartmental DisordersSARS-CoV-2 and COVID-19 ResearchInflammatory Myopathies and Dermatomyositis
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