11C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography- computed tomography
A. V. Ozerskaya, Tatiana N. Zamay, Olga S. Kolovskaya, Nikolay А. Tokarev, Кirill V. Belugin, N. G. Chanchikova, O.N. Badmaev, Galina S. Zamay, Irina A. Shchugoreva, Roman V. Moryachkov, V. N. Zabluda, Vladimir А. Khorzhevskii, Н. В. Шепелевич, S.V. Gappoev, Е. А. Карлова, A. S. Saveleva, Alexander A. Volzhentsev, Anna N. Blagodatova, Kirill A. Lukyanenko, Dmitry V. Veprintsev, T. E. Smolyarova, Felix N. Tomilin, Sergey S. Zamay, Vladimir N. Silnikov, Maxim V. Berezovski, Anna S. Kichkailo
Abstract
C radionuclide with an ultra-short (20.38 min) half-life is considered safest for PET/CT imaging and does not cause false-positive results in heart imaging. Its combination with aptamers gives us high-specificity and high-contrast imaging of cancer cells and can be applied for PET/CT-guided drug delivery in cancer therapies.