Therapeutic implications of germline vulnerabilities in DNA repair for precision oncology
Shreya M. Shah, Elena V. Demidova, Randy W. Lesh, Michael J. Hall, Mary B. Daly, Joshua E. Meyer, Martin J. Edelman, Sanjeevani Arora
Topics & Concepts
MedicineDNA repairPARP inhibitorGermlineDNA mismatch repairPrecision medicineSynthetic lethalityImmune checkpointCancer researchPoly ADP ribose polymeraseBioinformaticsCancerOncologyGeneticsGenePolymeraseInternal medicineBiologyImmunotherapyPathologyPARP inhibition in cancer therapyCancer Genomics and DiagnosticsGenetic factors in colorectal cancer