HPLC-assisted automated oligosaccharide synthesis: the implementation of the two-way split valve as a mode of complete automation
Matteo Panza, Keith J. Stine, Alexei V. Demchenko
Abstract
Reported herein is the development of a user-friendly platform for simple and transformative automation based on standard HPLC equipment. We showcase how the improved platform works in application to the completely automated, a "press of the button," synthesis of various glycan sequences.
Topics & Concepts
AutomationTransformative learningComputer scienceSimple (philosophy)High-performance liquid chromatographyMode (computer interface)ChemistryEmbedded systemChromatographyCombinatorial chemistryProcess engineeringEngineeringHuman–computer interactionMechanical engineeringPsychologyEpistemologyPhilosophyPedagogyCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchEnzyme Catalysis and Immobilization