The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
Hui Chen, Mindy Smith, Jasmin Herz, Tong Li, Rebecca B. Hasley, Cécile Le Saout, Ziang Zhu, Jie Cheng, Andres Gronda, José A. Martina, Pablo M. Irusta, Tatiana Karpova, Dorian B. McGavern, Marta Catálfamo
Abstract
mice have reduced cytokine-producing T cells in response to a lymphocytic choriomeningitis virus (LCMV) infection and fail to efficiently control the virus. Specific deletion of PAR1 in LCMV GP33-specific CD8 T cells results in reduced expansion and diminished effector function. These data demonstrate that PAR1 plays a role in T cell activation and function, and this pathway could represent a new therapeutic strategy to modulate CD8 T cell effector function.
Topics & Concepts
EffectorCell biologyChemistryCD8Signal transductionReceptorBiologyBiochemistryImmunologyImmune systemBlood Coagulation and Thrombosis MechanismsCoagulation, Bradykinin, Polyphosphates, and AngioedemaComplement system in diseases