Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn
Jue Zhang, Jackie Chang, M. A. Beg, Wenxin Huang, Yiqiong Zhao, Wen Dai, Xiaopeng Wu, Weiguo Cui, Sneha S. Pillai, Hari Vishal Lakhani, Komal Sodhi, Joseph I. Shapiro, Daisy Sahoo, Ze Zheng, Roy L. Silverstein, Yiliang Chen
Abstract
mice. Additionally, LPS induced a higher extent of the metabolic switch from oxidative phosphorylation to glycolysis. Mechanistically, NKA α1 interacted with TLR4 and Lyn. The presence of NKA α1 in this complex attenuated Lyn activation by LPS, which subsequently restricted the downstream ROS and NF-κB signaling. In conclusion, we demonstrated that NKA α1 suppresses LPS-induced macrophage pro-inflammatory signaling through Lyn.
Topics & Concepts
LYNChemistryCell biologySignal transductionPhosphorylationTLR4InflammationReactive oxygen speciesKinaseProto-oncogene tyrosine-protein kinase SrcBiologyImmunologyBiochemistryIon Transport and Channel RegulationNeonatal Respiratory Health Research