Sodium toluene‐4‐sulfonate as a reusable and ecofriendly catalyst for greener synthesis of 5‐aminopyrazole‐4‐carbonitrile in aqueous medium
Aboli C. Sapkal, Santosh Kamble
Abstract
Abstract In these environmentally conscious days there is need to use eco‐friendly greener technologies, such as solvent free, microwave, ultrasound and use of room temperature. Here report an efficient and green protocol for the synthesis of 5‐aminopyrazole‐4‐carbonitrile from three component condensation of phenyl hydrazine, aldehyde, and malononitrile using NaPTS as catalyst in aqueous medium. Use of water has emerged as a versatile solvent for organic reaction; it is readily available, inexpensive, environmentally benign, neutral and natural solvent. Multicomponent reactions in water are of outstanding value in organic synthesis and green chemistry. The significant features of this article are short reaction time, provide excellent yield, removal of toxic solvent and use of water as green solvent.