Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization
Anna Marie Sokac, Natalie Biel, Stefano De Renzis
Abstract
During morphogenesis, changes in the shapes of individual cells are harnessed to mold an entire tissue. These changes in cell shapes require the coupled remodeling of the plasma membrane and underlying actin cytoskeleton. In this review, we highlight cellularization of the Drosophila embryo as a model system to uncover principles of how membrane and actin dynamics are co-regulated in space and time to drive morphogenesis.
Topics & Concepts
MorphogenesisCell biologyActinCytoskeletonDrosophila (subgenus)Actin cytoskeletonBiologyCellGeneticsGeneCellular Mechanics and InteractionsMicrotubule and mitosis dynamicsBiocrusts and Microbial Ecology