Characterization of antisense oligonucleotide and guide ribonucleic acid diastereomers by hydrophilic interaction liquid chromatography coupled to mass spectrometry
Alexandre Goyon, Molly S. Blevins, José G. Napolitano, Daniel Nguyen, Meenakshi Goel, Brandon Scott, Jenny Wang, Stefan G. Koenig, Tao Chen, Kelly Zhang
Topics & Concepts
ChemistryHydrophilic interaction chromatographyOligonucleotideDiastereomerMass spectrometryChromatographyCombinatorial chemistryBiochemistryStereochemistryHigh-performance liquid chromatographyDNADNA and Nucleic Acid ChemistryRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques