N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties
Shuyuan Wang, Yue Xu, Yan Zhao, Shun Zhang, Min Li, Xiaowei Li, Jinzhao He, Hong Zhou, Zemei Ge, Runtao Li, Baoxue Yang
Topics & Concepts
ChemistryBioavailabilityDiureticPharmacologyUreaIn vivoOral administrationCarboxamideBiochemistryMedicineBiologyBiotechnologyElectrolyte and hormonal disordersIon Transport and Channel RegulationAmino Acid Enzymes and Metabolism