Toxico-metabolomics study of a deep eutectic solvent comprising choline chloride and urea suggests <i>in vivo</i> toxicity involving oxidative stress and ammonia stress
Dasom Jung, Jae Back Jung, Seulgi Kang, Ke Li, Inseon Hwang, Ji Hoon Jeong, Hyung Sik Kim, Jeongmi Lee
Abstract
The <italic>in vitro</italic> and <italic>in vivo</italic> studies suggest that choline chloride-based deep eutectic solvents may not be considered as pure, safe mixtures even if they consist of safe compounds.
Topics & Concepts
Choline chlorideDeep eutectic solventIn vivoEutectic systemCholineUreaChemistryAmmoniaSolventChlorideOxidative stressToxicityOrganic chemistryInorganic chemistryNuclear chemistryBiochemistryBiologyBiotechnologyAlloyIonic liquids properties and applicationsAlkaloids: synthesis and pharmacologyChemical Synthesis and Reactions