Small-Molecule Mn Antioxidants in Caenorhabditis elegans and Deinococcus radiodurans Supplant MnSOD Enzymes during Aging and Irradiation
Elena K. Gaidamakova, Ajay Sharma, Vera Y. Matrosova, Olga Grichenko, Robert P. Volpe, Rok Tkavc, Isabel H. Conze, Polina Klimenkova, Irina A. Balygina, William H. Horne, Cene Gostinčar, Xiao Chen, Kira S. Makarova, Igor Shuryak, Chandra Srinivasan, Belinda Jackson‐Thompson, Brian M. Hoffman, Michael J. Daly
Abstract
The current theory of cellular defense against oxidative damage identifies antioxidant enzymes as primary defenders against ROS, with MnSOD being the preeminent superoxide (O 2 •− ) scavenger. However, MnSOD is shown to be dispensable both for radiation resistance and longevity in model organisms, the bacterium Deinococcus radiodurans and the nematode Caenorhabditis elegans .
Topics & Concepts
Deinococcus radioduransCaenorhabditis elegansEnzymeDeinococcusChemistryBiologyMicrobiologyBiochemistryDNAGeneMetal-Catalyzed Oxygenation MechanismsMitochondrial Function and PathologyGlutathione Transferases and Polymorphisms