The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM
Tongyi Dou, Tengfei Lian, Shi Shu, Yi He, Jiansen Jiang
Topics & Concepts
TransporterProbenecidOrganic anion transporter 1ChemistryBiochemistryBinding siteDrugSolute carrier familyPlasma protein bindingOrganic cation transport proteinsATP-binding cassette transporterBinding affinitiesSubstrate (aquarium)PharmacologyBiologyReceptorGeneEcologyDrug Transport and Resistance MechanismsAmino Acid Enzymes and MetabolismTrace Elements in Health