A kinase cascade on the yeast lysosomal vacuole regulates its membrane dynamics: conserved kinase Env7 is phosphorylated by casein kinase Yck3
Surya P. Manandhar, Ikha M. Siddiqah, Stephanie M. Cocca, Editte Gharakhanian
Abstract
). This study represents the first report on the regulatory mechanism of an STK16-related kinase. It also points to regulation of vacuolar membrane dynamics via a novel Yck3-Env7 kinase cascade.
Topics & Concepts
Casein kinase 2Casein kinase 1Cell biologyMitogen-activated protein kinase kinaseKinaseMAP kinase kinase kinaseChemistryProtein kinase ABiochemistryPhosphorylationMAP2K7ASK1Cyclin-dependent kinase 9BiologyCyclin-dependent kinase 2Cellular transport and secretionLysosomal Storage Disorders ResearchCalcium signaling and nucleotide metabolism