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Tethered Tungsten-Alkylidenes for the Synthesis of Cyclic Polynorbornene via Ring Expansion Metathesis: Unprecedented Stereoselectivity and Trapping of Key Catalytic Intermediates

Vineet K. Jakhar, Digvijayee Pal, Ion Ghiviriga, Khalil A. Abboud, Daniel W. Lester, Brent S. Sumerlin, Adam S. Veige

2021Journal of the American Chemical Society45 citationsDOI

Abstract

This report describes an approach for preparing tethered tungsten-imido alkylidene complexes featuring a tetra-anionic pincer ligand. Treating the tungsten alkylidyne [tBuOCO]W≡CtBu(THF)2 (1) with isocyanates (RNCO; R = tBu, Cy, and Ph) leads to cycloaddition occurring exclusively at the C═N bond to generate the tethered tungsten-imido alkylidenes (6-NR). Unanticipated intermediates reveal themselves, including the discovery of [(O2CtBuC═)W(η2-(N,C)-RNCO)(THF)] (11-R) and an unprecedented decarbonylation product [(tBuOCO)W(≡NR)(tBuCCO)] (14-R), on the pathway to the formation of 6-NR. Complex 11-R is kinetically stable for sterically bulky isocyanate R = tBu (11-tBu) and is isolated and characterized by single-crystal X-ray diffraction. Finally, adding to the short list of catalysts capable of ring expansion metathesis polymerization (REMP), complexes 6-NR and 11-tBu are active for the stereoselective synthesis of cyclic polynorbornene.

Topics & Concepts

ChemistryMetathesisSteric effectsPincer ligandStereoselectivityCycloadditionDecarbonylationStereochemistryLigand (biochemistry)CatalysisIsocyanateRing (chemistry)PolymerizationMedicinal chemistryPincer movementOrganic chemistryPolymerReceptorBiochemistryPolyurethaneSynthetic Organic Chemistry MethodsOrganometallic Complex Synthesis and CatalysisFerrocene Chemistry and Applications
Tethered Tungsten-Alkylidenes for the Synthesis of Cyclic Polynorbornene via Ring Expansion Metathesis: Unprecedented Stereoselectivity and Trapping of Key Catalytic Intermediates | Litcius