FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma
Giulia Cristinziano, Manuela Porru, Dante Lamberti, Simonetta Buglioni, Francesca Rollo, Carla Azzurra Amoreo, Isabella Manni, Diana Giannarelli, Cristina Cristofoletti, Giandomenico Russo, Mitesh J. Borad, Gian Luca Grazi, Maria Grazia Diodoro, Silvia Giordano, Andrea Sacconi, Mattia Forcato, Sergio Anastasi, Carlo Leonetti, Oreste Segatto
Topics & Concepts
OrganoidCancer researchCDKN2ABiologyPhenotypeTyrosine kinaseFusion proteinMAPK/ERK pathwayTransplantationReceptor tyrosine kinaseFusion geneTranscriptomeKinaseSignal transductionCancerGeneCell biologyMedicineGeneticsInternal medicineGene expressionRecombinant DNAFibroblast Growth Factor ResearchLiver physiology and pathologyCholangiocarcinoma and Gallbladder Cancer Studies