Evaluation of polygenic risk score for risk prediction of gastric cancer
Xiaoyu Wang, Lili Wang, Lin Xu, Shu-Zhen Liang, Meng-Chao Yu, Qiuyue Zhang, Quanjiang Dong
Abstract
genomic variations, cancer associated bacteria members in the gastric microbiome, discussed the potentials for performance improvement of PRS models with these microbial factors. Future studies on comprehensive PRS models established with human SNPs, epidemiological factors and microbial factors are indicated.
Topics & Concepts
MedicineSingle-nucleotide polymorphismCancerSNPEpidemiologyHelicobacter pyloriRisk assessmentPolygenic risk scoreInternal medicineOncologyGenotypeGeneticsBiologyGeneComputer scienceComputer securityHelicobacter pylori-related gastroenterology studiesGastric Cancer Management and OutcomesCancer-related molecular mechanisms research