AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz Bauernfeind, Gábor Horváth, Daniel R. Caffrey, Eicke Latz, Katherine A. Fitzgerald
Topics & Concepts
AIM2Pyrin domainInflammasomeCell biologyPattern recognition receptorBiologyTLR3Signal transducing adaptor proteinIRF3Caspase 1Innate immune systemMolecular biologyChemistrySignal transductionToll-like receptorReceptorBiochemistryInflammasome and immune disordersinterferon and immune responsesImmune Response and Inflammation