Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An <i>in Silico</i> and <i>in Vitro</i> Study
Maša Kenda, Nataša Karas Kuželički, Mitsuru Iida, Hiroyuki Kojima, Marija Sollner Dolenc
Abstract
BACKGROUND: testing is now banned completely in the European Union. OBJECTIVES: . METHODS: , MDA-kb2, and GH3.TRE-Luc cell lines. Additionally, assays to test for false positives were used (nonspecific luciferase gene induction and luciferase inhibition). RESULTS: . DISCUSSION: These data support the concerns of regulatory authorities about the endocrine-disrupting potential of preservatives. These data also define the need to further determine their effects on the endocrine system and the need to reassess the risks they pose to human health and the environment. https://doi.org/10.1289/EHP6596.
Topics & Concepts
TriclosanPharmacyLibrary scienceMedicineFamily medicinePathologyComputer scienceEffects and risks of endocrine disrupting chemicalsAnimal testing and alternativesChemistry and Chemical Engineering