Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors
Samantha Caputo, Simona Di Martino, Vincenzo Cilibrasi, Piero Tardia, Marco Mazzonna, Debora Russo, Ilaria Penna, Maria Summa, Sine Mandrup Bertozzi, Natalia Realini, Natasha Margaroli, Marco Migliore, Giuliana Ottonello, Min Liu, Peter T. Lansbury, Andrea Armirotti, Rosalia Bertorelli, Soumya S. Ray, Renato T. Skerlj, Rita Scarpelli
Abstract
enriches the arsenal of promising lead compounds that may therefore act as useful pharmacological tools for investigating the potential therapeutic effects of AC inhibition in relevant sphingolipid-mediated disorders.
Topics & Concepts
ChemistryOxazoleSphingolipidCarboxamideCeramideBiological activityPharmacologyLead compoundBiochemistryStereochemistryIn vitroBiologyApoptosisSphingolipid Metabolism and SignalingLysosomal Storage Disorders ResearchCarbohydrate Chemistry and Synthesis