Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer’s disease
Merve Erdoğan, Burcu Kılıç, Rahşan Ilıkçı Sağkan, Fatma Aksakal, Tuğba Erçeti̇n, Hayrettin Ozan Gülcan, Deniz S. Doğruer
Topics & Concepts
ChemistryBenzoxazoleBenzothiazoleIC50TacrineCytotoxicityAntioxidantStereochemistryDocking (animal)CholinesteraseCombinatorial chemistryLead compoundAcetylcholinesteraseStructure–activity relationshipEnzymePharmacologyIn vitroBiochemistryOrganic chemistryMedicineNursingCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity