Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers
Roberta Haddad-Tóvolli, Joseane Morari, Roberta Barbizan, Vanessa Cristina Dias Bóbbo, Rodrigo S. Carraro, Carina Solon, Nathalia Romanelli Vicente Dragano, Márcio Alberto Torsoni, Eliana P. Araújo, Lı́cio A. Velloso
Abstract
Maternal dietary habits directly influence offspring health. In this study, we aimed at determining the impact of maternal obesity on BBB integrity. We show that DIO offspring presented a leakier ME-BBB, accompanied by changes in the expression of transcripts encoding for endothelial and tanycytic proteins, as well as of hypothalamic neuropeptides. Breastfeeding in lean dams was sufficient to protect the offspring from ME-BBB disruption, providing a preventive strategy of nutritional intervention during early life.
Topics & Concepts
OffspringBlood–brain barrierBreastfeedingObesityBiologyIntervention (counseling)Median eminenceMedicineEndocrinologyPhysiologyInternal medicinePregnancyHypothalamusCentral nervous systemPathologyGeneticsPsychiatryBirth, Development, and HealthRegulation of Appetite and ObesityNeuroscience of respiration and sleep