Clinical severity of LTP syndrome is associated with an expanded IgE repertoire, FDEIA, FDHIH, and LTP mono reactivity
Enrico Scala, Damiano Abeni, Valeria Rachela Villella, Danilo Villalta, Lorenzo Cecchi, Valerio Pravettoni, Mauro Giani, Elisabetta Caprini, Riccardo Asero
Abstract
Summary: Clinical severity of LTP syndrome is associated with an expanded IgE repertoire in terms of the number of LTP components recognized and increased IgE levels in individual molecules. Ara h 9, Cor a 8, and Mal d 3 showed the strongest association with clinical severity. In addition, several cofactors may either exacerbate (FDEIA, FDHIH, and LTP monoreactivity) or ameliorate (atopic dermatitis and co-sensitization to profilin and/or PR10) individual patient outcomes. These factors may be utilized for the daily clinical management of LTP syndrome.
Topics & Concepts
MedicineLong-term potentiationSensitizationImmunoglobulin EImmunologyAtopic dermatitisAllergyInternal medicineAntibodyReceptorAllergic Rhinitis and SensitizationContact Dermatitis and AllergiesDermatology and Skin Diseases