Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression
Jingyuan Wan, Ge Kuang, Li Zhang, Rong Jiang, Yongtao Chen, Zhen He, Duyun Ye
Topics & Concepts
HesperetinOxidative stressPharmacologyAcetaminophenReactive oxygen speciesProinflammatory cytokineLiver injuryChemistryHepatocyteApoptosisHeme oxygenaseInflammationBiochemistryMedicineAntioxidantImmunologyHemeIn vitroFlavonoidEnzymeDrug-Induced Hepatotoxicity and ProtectionHeme Oxygenase-1 and Carbon MonoxideInflammasome and immune disorders