Targeting long noncoding RNA PMIF facilitates osteoprogenitor cells migrating to bone formation surface to promote bone formation during aging
Dijie Li, Jin Liu, Chaofei Yang, Ye Tian, Chong Yin, Lifang Hu, Zhihao Chen, Fan Zhao, Ru Zhang, Aiping Lü, Ge Zhang, Airong Qian
Abstract
Toward translational medicine, this study hints that targeting lnc-PMIF to facilitate aged OPCs migrating to bone formation surface could be a brand-new anabolic strategy for aging-related osteoporosis.
Topics & Concepts
Gene knockdownCell biologyMesenchymal stem cellOsteoblastChemistryCellRNASmall interfering RNACell migrationIn vitroBiologyBiochemistryGeneBone Metabolism and DiseasesMacrophage Migration Inhibitory FactorCircular RNAs in diseases