The Role of Zinc in Cardiovascular Disease
Farhana Begum, Hay Me Me, Marta Christov
Abstract
Zinc is an essential trace element due to its role as a key part of human enzymatic activity. As a cofactor in metalloenzymes and metalloproteins, zinc participates in diverse biological functions, including gene transcription, translation, and replication, phagocytosis, and immunoglobulin and cytokine production. In this review, we will focus on the role of zinc in the cardiovascular system, including heart failure, vascular calcification, and myocardial infarction. We will further highlight the role of zinc in cardiovascular pathology in individuals with chronic kidney disease, and type II diabetes mellitus, groups uniquely at risk for cardiovascular morbidity and mortality.
Topics & Concepts
MedicineZincDiseaseDiabetes mellitusKidney diseaseKidneyInternal medicineCytokineImmunologyCoronary heart diseaseBioinformaticsMetabolic syndromeAntibodyType 2 diabetesRisk factorInflammationEnzymePathogenesisEndocrinologyCoronary artery diseaseTrace Elements in HealthPlant Micronutrient Interactions and EffectsCardiac Fibrosis and Remodeling