Visible-light-mediated deoxygenative transformation of 1,2-dicarbonyl compounds through energy transfer process
Yun-Xuan Luo, Jie Huang, Guojiao Wu, Xiang‐Ying Tang, Jinping Qu
Abstract
Through the energy transfer process, mild transformations can be achieved that are often difficult to realize under thermodynamic conditions. Herein, a visible-light-driven deoxygenative coupling of 1,2-dicarbonyl compounds for C–O, C–S, and C–N bonds construction is developed via triplet state 1,2-dicarbonyls, affording a wide range of α-functionalized ketones/esters under transition-metal and external photocatalyst free conditions. The usefulness of this method is demonstrated by gram-scale synthesis, late-stage functionalization of various carboxylic acid drugs, and the synthesis of natural products and drug molecules. Visible-light photochemistry, which includes energy transfer processes, can enable transformations that are difficult or prohibited from thermal pathways. Here, the authors develop a deoxygenative coupling of 1,2-dicarbonyl compounds with a variety of nucleophiles via energy transfer.