Nose-to-Brain: The Next Step for Stem Cell and Biomaterial Therapy in Neurological Disorders
Natalia Villar-Gómez, Doddy Denise Ojeda-Hernández, Eneritz López-Muguruza, Silvia García-Flores, Natalia Bonel-García, María Soledad Benito‐Martín, B. Selma-Calvo, Alejandro A. Canales-Aguirre, Juan Carlos Mateos‐Díaz, Paloma Montero‐Escribano, Jordi A. Matías‐Guiu, Jorge Matías‐Guiu, Ulises Gómez‐Pinedo
Abstract
Neurological disorders are a leading cause of morbidity worldwide, giving rise to a growing need to develop treatments to revert their symptoms. This review highlights the great potential of recent advances in cell therapy for the treatment of neurological disorders. Through the administration of pluripotent or stem cells, this novel therapy may promote neuroprotection, neuroplasticity, and neuroregeneration in lesion areas. The review also addresses the administration of these therapeutic molecules by the intranasal route, a promising, non-conventional route that allows for direct access to the central nervous system without crossing the blood-brain barrier, avoiding potential adverse reactions and enabling the administration of large quantities of therapeutic molecules to the brain. Finally, we focus on the need to use biomaterials, which play an important role as nutrient carriers, scaffolds, and immune modulators in the administration of non-autologous cells. Little research has been conducted into the integration of biomaterials alongside intranasally administered cell therapy, a highly promising approach for the treatment of neurological disorders.