A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells
Rajiv Lochan Tiwari, Pratibha Mishra, Nicola Martin, Nikhil Oommen George, Vadim Sakk, Karin Soller, Kodandaramireddy Nalapareddy, Kalpana Nattamai, Karin Scharffetter‐Kochanek, Maria Carolina Florian, Hartmut Geiger
Abstract
with CASIN induced anagen onset and increased the percentage of anagen skin areas. Aging-associated functional deficits of HFSCs are at least in part intrinsic to HFSCs and can be restored by rational pharmacological approaches.
Topics & Concepts
RejuvenationWNT5AHair follicleStem cellCell biologyCDC42BiologyHair growthWnt signaling pathwaySignal transductionPhysiologyGeneticsHair Growth and DisordersWnt/β-catenin signaling in development and cancerSkin and Cellular Biology Research