Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors
Xiandeng Li, Tao Yang, Mengshi Hu, Yingxue Yang, Minghai Tang, Dexin Deng, Kongjun Liu, Suhong Fu, Yan Tan, Huan Wang, Yong Chen, Chufeng Zhang, Yong Guo, Bin Peng, Wenting Si, Zhuang Yang, Lijuan Chen
Topics & Concepts
ChemistryKinasePyridineTyrosine kinasePharmacologyStructure–activity relationshipIn vitroCancer researchStereochemistryBiochemistrySignal transductionBiologyMedicinal chemistryChronic Lymphocytic Leukemia ResearchCancer Mechanisms and TherapyAdvanced Breast Cancer Therapies