Design, synthesis and antitumor evaluation of novel pyrazolo[3,4- <i>d</i> ]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors
Ibrahim M. Salem, Samia M. Mostafa, Ismail Salama, Osama I. El‐Sabbagh, Wael A. H. Hegazy, Tarek S. Ibrahim
Abstract
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Topics & Concepts
Dihydrofolate reductaseApoptosisMethotrexateLipinski's rule of fiveChemistryAntifolateAmino acidDocking (animal)CytotoxicityEnzymeCell cultureBiochemistryPyrimidineCaspaseIn vitroCancer cellPharmacologyBiologyProgrammed cell deathCancerAntimetaboliteImmunologyMedicineGeneticsGeneNursingIn silicoSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activityComputational Drug Discovery Methods