Litcius/Paper detail

Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors

Rom Keshet, Joo Sang Lee, Lital N. Adler, Muhammed Iraqi, Yarden Ariav, Lisha Qiu Jin Lim, Shaul Lerner, Shiran Rabinovich, Roni Oren, Rotem Katzir, Hila Weiss Tishler, Noa Stettner, Omer Goldman, Hadas Landesman, Sivan Galai, Yael Kuperman, Yuri Kuznetsov, Alexander Brandis, Tevi Mehlman, Sergey Malitsky, Maxim Itkin, S. Eleonore Koehler, Yongmei Zhao, Keyur Talsania, Tsai-Wei Shen, Nir Peled, Igor Ulitsky, Angel Porgador, Eytan Ruppin, Ayelet Erez

2020Nature Cancer102 citationsDOI

Topics & Concepts

Immune systemCancer researchImmune checkpointDownregulation and upregulationCD8Phosphoenolpyruvate carboxykinaseCancer cellCancerChemistryImmunotherapyBiologyBiochemistryImmunologyInternal medicineMedicineEnzymeGeneCancer Research and TreatmentsBiochemical and Molecular ResearchCancer, Hypoxia, and Metabolism