Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates
Kazuya Kanemoto, Yuki Sakata, Takamitsu Hosoya, Suguru Yoshida
Abstract
Novel synthetic methods for phenoxathiins and phenothiazines by aryne reactions are disclosed. We found that phenoxathiins were efficiently prepared by the reaction between aryne intermediates and S-(2-hydroxyaryl) 4-toluenethiosulfonates. A synthetic method for phenothiazines was also developed by the reaction of arynes with S-(2-aminoaryl) 4-toluenethiosulfonates.
Topics & Concepts
ChemistryAryneMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryCyclization and Aryne ChemistryChemical synthesis and alkaloidsChemical Reactions and Mechanisms