MED13L integrates Mediator-regulated epigenetic control into lung cancer radiosensitivity
Nasha Zhang, Yemei Song, Yeyang Xu, Jiandong Liu, Yue Shen, Liqing Zhou, Jinming Yu, Ming Yang
Abstract
Our study linking PRKCA to radiosensitivity through a novel mechanism may enable the rational targeting of PRKCA to unlock therapeutic potentials of NSCLC.
Topics & Concepts
RadiosensitivityRadioresistanceCancer researchMediatorGene silencingBiologyChromatin immunoprecipitationLung cancerRadiation therapyMedicineCell biologyPromoterGene expressionGenePathologyInternal medicineCell cultureGeneticsRNA modifications and cancerCircular RNAs in diseasesCancer-related molecular mechanisms research