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Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome

Guohao Wang, Weiqin Yin, Hyun‐Hee Shin, Qingjun Tian, Wei Lü, Steven X. Hou

2021Nature Aging33 citationsDOI

Topics & Concepts

InflammasomeNeurodegenerationMicrogliaNeuroscienceNeuroinflammationChemistryCell biologyBiologyInflammationMedicineImmunologyPathologyDiseaseNeuroinflammation and Neurodegeneration MechanismsInflammasome and immune disordersMacrophage Migration Inhibitory Factor
Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome | Litcius