SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma
Hongfa Xu, Hao Wang, Wei Zhao, Sirui Fu, Yong Li, Wenjun Ni, Yongjie Xin, Wei Li, Chenzi Yang, Yanyan Bai, Meixiao Zhan, Ligong Lu
Abstract
: This study revealed a novel mechanism of SUMOylated Mettl3-mediated Snail mRNA homeostasis, identifying the UBC9/SUMOylated Mettl3/Snail axis as a novel mediator of the SUMO pathway involved in HCC progression.
Topics & Concepts
SUMO proteinGene knockdownMethyltransferaseDownregulation and upregulationBiologyCancer researchOncogeneCell biologyMolecular biologyApoptosisUbiquitinCell cycleMethylationBiochemistryGeneRNA modifications and cancerCancer-related gene regulationHVDC Systems and Fault Protection