(1-Selenocyanatoethyl)benzene: A Selenocyanation Reagent for Site-Selective Selenocyanation of Inert Alkyl C(sp<sup>3</sup>)–H Bonds
Fei Yu, Chuang Li, Chuangye Wang, Hongwei Zhang, Zhong‐Yan Cao
Abstract
A new, simple, yet easily accessible, (1-selenocyanatoethyl)benzene has been designed and applied as a SeCN group transfer reagent for selenocyanation of aliphatic C(sp3)–H bonds for the first time. This protocol is featured with mild reaction conditions and wide substrate scope. Control experiments reveal that a radical-group transfer mechanism might be involved.
Topics & Concepts
ChemistryReagentBenzeneAlkylSubstrate (aquarium)InertFunctional groupMedicinal chemistryGroup (periodic table)Combinatorial chemistryOrganic chemistryGeologyOceanographyPolymerCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesRadical Photochemical Reactions