Incorporation of disulfide bonds into ionizable lipids enables efficient splenic mRNA delivery and potent immunotherapy in mice
Yichen Li, Yi Cao, Hao Bai, Luwei Zhang, Baiqiu Chen, Chengfan Wu, Qi Shuai, Yunfeng Yan
Topics & Concepts
Disulfide bondImmunotherapyChemistryMessenger RNASpleenBiochemistryImmunologyMedicineImmune systemGeneRNA Interference and Gene DeliveryVirus-based gene therapy researchAdvanced biosensing and bioanalysis techniques