Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy
Qingwen Qi, Qian Wang, Yuhao Li, Dionisio Zaldívar, María Eliana Lanio Ruiz, Ruizhuo Ouyang, Baolin Liu, Yuqing Miao
Abstract
Rhenium (Re) is widely used in the diagnosis and treatment of cancer due to its unique physical and chemical properties. Re has more valence electrons in its outer shell, allowing it to exist in a variety of oxidation states and to form different geometric configurations with many different ligands. The luminescence properties, lipophilicity, and cytotoxicity of complexes can be adjusted by changing the ligand of Re. This article mainly reviews the development of radionuclide 188Re in radiotherapy and some innovative applications of Re as well as the different therapeutic approaches and imaging techniques used in cancer therapy. In addition, the current application and future challenges and opportunities of Re are also discussed.