The ARM repeat domain of hemocyanin interacts with MKK4 to modulate antimicrobial peptides expression
Jude Juventus Aweya, Kaiying Zhuang, Yiqi Liu, Jiaohong Fan, Defu Yao, Fan Wang, Xiaohan Chen, Shengkang Li, Hongyu Ma, Yueling Zhang
Abstract
-Jun cascade proteins and their phosphorylation level, which consequently decreased AMPs expression. Further analysis revealed that PvHMC interacts via its armadillo (ARM) repeat domain with PvMKK4 to modulate the p38 MAPK signaling pathway. Thus, the ARM repeat domain enables penaeid shrimp hemocyanin to modulate AMPs expression during antimicrobial response by activating the p38 MAPK signaling pathway.
Topics & Concepts
Antimicrobial peptidesBiologyCell biologyp38 mitogen-activated protein kinasesMAPK/ERK pathwaySignal transductionProtein kinase AGene knockdownMicrobiologyPhosphorylationAntimicrobialBiochemistryGeneInvertebrate Immune Response MechanismsAquaculture disease management and microbiotaMosquito-borne diseases and control