Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant
Oswaldo A. Lozoya, Fuhua Xu, Dagoberto Grenet, Tianyuan Wang, Sara A. Grimm, Veronica Godfrey, Suramya Waidyanatha, Richard P. Woychik, Janine H. Santos
Abstract
locus in the skin but broadly affects the liver DNA methylome of the offspring. These effects are accompanied by altered gene expression programs that persist throughout life, and which associate with impairment of antioxidant activity and mitochondrial function in aged animals. These pervasive and lasting genomic effects suggest a putative role for mitochondria in regulating life-long gene expression programs through developmental nuclear epigenetic remodeling.
Topics & Concepts
EpigeneticsDNA methylationBiologyEpigenomeMitochondrial DNAGeneticsToxicantLocus (genetics)GeneMitochondrionMethylationOffspringGene expressionChemistryOrganic chemistryToxicityPregnancyEpigenetics and DNA MethylationBirth, Development, and HealthRNA modifications and cancer