Practical Guidelines for the Treatment of Gestational Trophoblastic Disease: Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)–European Society of Gynaecologic Oncology (ESGO)–Gynecologic Cancer InterGroup (GCIG)–International Society for the Study of Trophoblastic Diseases (ISSTD)
Christianne Lok, Nienke E. van Trommel, Elena Ioana Braicu, François Planchamp, Ross S. Berkowitz, Michael J. Seckl, Inge O. Baas, Alice Bergamini, Miguel Henriques Abreu, Pierre-Adrien Bolze, Geneviève Bouchard‐Fortier, Antônio Mendes da Costa Braga, Maria Stephanie Fay S. Cagayan, Antonio Casado, Min Chul Choi, John Coulter, Kevin M. Elias, Hind Elmalik, Andrea Garrett, Ehsan Ghorani, Andrea Gmür, Frédéric Goffin, François Golfier, Neil S. Horowitz, Ulrika Joneborg, Baljeet Kaur, Philip Tonui Kipkirui, Jacob Korach, Xin Lü, Izildinha Maestá, Giorgia Mangili, Gloria Marquina, Jérôme Massardier, Hys Ngan, Ray Osborne, Nelleke Ottevanger, Sinan Özalp, Naveed Sarwar, Paradan K. Sekharan, Franziska Siegenthaler, Olesya Solheim, Lone Sunde, Fred C.G.J. Sweep, Grzegorz Szewczyk, Manuela Undurraga, Emelie Wallin, Matthew Winter, Eiko Yamamoto, Benoît You, Emelie Wallin, Anneke M. Westermann, Yang Xiang, Ignacio Zapardiel
Abstract
Gestational trophoblastic diseases (GTDs) are a group of pregnancy-related premalignant and malignant diseases with generally a favorable prognosis when treated adequately. Many different treatment protocols exist worldwide. To our knowledge, this is the first set of global consensus-based guidelines for GTD. Four international organizations (European Organisation for the Treatment of Trophoblastic Diseases, European Society of Gynecologic Oncology, Gynecologic Cancer Intergroup, and International Society for the Study of Trophoblastic Diseases) delegated 53 expert GTD clinicians from 31 countries who formulated nine consensus-based definitions and the minimum criteria required to be a GTD center. Furthermore, 18 flow diagrams were developed to diagnose, treat, and follow up all forms of primary or recurrent GTD. The definitions and flow diagrams were drafted and adapted in consecutive (online) meetings until consensus was reached followed by an external review process. Here, the final guidelines are presented together with the available supporting evidence from the literature.