RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation
Hetao Bian, Ling Xiao, Liang Liang, Yinping Xie, Huiling Wang, Gaohua Wang
Topics & Concepts
NeuroinflammationTLR4LipopolysaccharidePharmacologyWestern blotPyrin domainBehavioural despair testHDAC3MicrogliaReceptorChemistryImmunologyMedicineHistone deacetylaseEndocrinologyInternal medicineHippocampusInflammationAntidepressantInflammasomeBiochemistryHistoneGeneTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol