Restorative functions of Autologous Stem Leydig Cell transplantation in a Testosterone-deficient non-human primate model
Kai Xia, Hong Chen, Jiancheng Wang, Xin Feng, Yong Gao, Yi Wang, Rongda Deng, Chunxing Wu, Peng Luo, Min Zhang, Chao Wang, Yong Zhang, Yadong Zhang, Guihua Liu, Xiang-An Tu, Xiangzhou Sun, Weiqiang Li, Qiong Ke, Chunhua Deng, Andy Peng Xiang
Abstract
For the first time, our short-term observations demonstrated that autologous SLCs can increase testosterone levels and ameliorate relevant TD symptoms in primate models. A larger cohort with long-term follow-up will be required to assess the translational potential of autologous SLCs for TD therapy.
Topics & Concepts
Leydig cellPrimateTransplantationTestosterone (patch)Nonhuman primateStem cellMedicineBiologyAndrologyInternal medicineNeuroscienceCell biologyHormoneEvolutionary biologyLuteinizing hormoneHormonal and reproductive studiesSperm and Testicular FunctionReproductive Biology and Fertility