Silver(<scp>i</scp>) complexes bearing heterocyclic thioamide ligands with NH<sub>2</sub> and CF<sub>3</sub> substituents: effect of ligand group substitution on antibacterial and anticancer properties
Despoina Varna, Elena Geromichalou, Antonios G. Hatzidimitriou, Rigini Papi, George Psomas, Panagiotis Dalezis, P. Aslanidis, Theodora Choli‐Papadopoulou, Dimitrios T. Trafalis, Panagiotis A. Angaridis
Abstract
antioxidant ability for scavenging free radicals, suggesting likely implication of this property in the mechanism of their bioactivity, but a low potential to destroy the double-strand structure of CT-DNA by intercalation. Complementary insights into possible bioactivity mechanisms were provided by molecular docking calculations, exploring the ability of complexes to bind to bacterial DNA gyrase, and to the overexpressed in the aforementioned cancer cells Fibroblast Growth Factor Receptor 1, affecting their functionalities.
Topics & Concepts
ThioamideChemistryThiolStereochemistryLigand (biochemistry)Medicinal chemistryXantphosTrifluoromethylEtherAntibacterial activitySelectivityCytotoxicityIn vitroOrganic chemistryReceptorBiochemistryArylBacteriaAlkylGeneticsBiologyCatalysisMetal complexes synthesis and propertiesSynthesis and Characterization of Heterocyclic CompoundsClick Chemistry and Applications